Although common in all age groups, the virus commonly attacks children probably due to the immature muscle cells. Prevalence of the disease is more in males as compared to females. During the viral myositis, serum creatine kinase is elevated and the muscle biopsy reveals degeneration of muscle fibers with the leukocyte infiltration and muscle necrosis.
Viral myositis may be subacute, acute or chronic. While acute and sub-acute myositis is generally self-limiting and the condition subsides within a few days, chronic form of the disease requires medications and is the result of chronic viral infection which has progressed to muscles. Some cases of viral myositis may cause rhabdomyolysis. Direct Infection.
In these cases, the virus directly affects the muscles resulting in disruption of the muscular structure. Whenever any foreign particles such as virus enter the body, it triggers the immune system. The immune system releases inflammatory mediators in response to the virus or other foreign particles. The inflammation may reach to the muscles causing myopathy.
Other mechanisms through which a virus causes myositis includes molecular mimicry, and persistent infections. It has also been seen that the treatment of patients through antiretroviral drug may also result in myositis; Antiretroviral drugs such as Zidovudine functions by inhibiting the viral DNA polymerase and helps in managing HIV infection.
However, during the process, these drugs also inhibit various critical enzymes of the human cells such as DNA polymerase beta and mitochondrial DNA polymerase gamma. Section Navigation. Facebook Twitter LinkedIn Syndicate. Symptoms, Diagnosis, and Treatment. Minus Related Pages. Symptoms Most people infected with Heartland virus experience fever, fatigue feeling tired , decreased appetite, headache, nausea, diarrhea, and muscle or joint pain.
Many are hospitalized because of their symptoms. Some people also have lower than normal counts of white blood cells cells that help fight infections and lower than normal counts of platelets which help clot blood. Sometimes tests to check how well the liver is working liver function tests can show increased levels of liver enzymes. Dilated cardiomyopathy Hypertrophic cardiomyopathy. Request an Appointment at Mayo Clinic. Dilated cardiomyopathy Open pop-up dialog box Close.
Dilated cardiomyopathy Compared with a normal heart, a heart with dilated cardiomyopathy has enlarged chambers of the heart, which can lead to heart failure if left untreated.
Hypertrophic cardiomyopathy Open pop-up dialog box Close. Hypertrophic cardiomyopathy Illustrations of a normal heart left and a heart with hypertrophic cardiomyopathy. Enlarged heart, in heart failure Open pop-up dialog box Close. Enlarged heart, in heart failure As the heart weakens, as it can with heart failure, it begins to enlarge, forcing the heart to work harder to pump blood on to the rest of the body.
Joelle's journey to a new heart Cardiomyopathy is a medical term for a number of genetic and nongenetic diseases involving the heart muscle that adversely affect the heart's mechanical pumping function and its electrical system.
Share on: Facebook Twitter. Show references Cooper LT. Definition and classification of the cardiomyopathies. Accessed Feb. What is cardiomyopathy in adults? American Heart Association. National Heart, Lung, and Blood Institute. Jameson JL, et al. Cardiomyopathy and myocarditis.
In: Harrison's Principles of Internal Medicine. McGraw Hill; Long B, et al. American Journal of Emergency Medicine ; doi Giustino G, et al. Journal of the American College of Cardiology. Mankad R expert opinion.
0コメント